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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Hypertension and atrial fibrillation

Orson Go1, Clive Rosendorff

  • 1Mount Sinai School of Medicine, Medicine (111), James J. Peters VA Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA.

Current Cardiology Reports
|October 30, 2009
PubMed

Insights

Uncontrolled hypertension contributes to atrial fibrillation (AF) through atrial remodeling. Medications targeting the renin-angiotensin system may help prevent AF onset and recurrence.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Electrophysiology

Background:

  • Atrial fibrillation (AF) represents a growing public health concern.
  • Uncontrolled hypertension is the primary risk factor for developing chronic AF.
  • Hypertension-induced atrial remodeling is a key mechanism in AF development.

Purpose of the Study:

  • To review the role of the renin-angiotensin system in atrial remodeling and AF.
  • To evaluate the potential of ACE inhibitors and ARBs in AF prevention.
  • To discuss ongoing research in AF prevention strategies.

Main Methods:

  • Review of experimental evidence on the renin-angiotensin system and atrial remodeling.
  • Analysis of retrospective data from clinical trials on ACE inhibitors and ARBs.
  • Consideration of ongoing prospective trials for AF prevention.

Main Results:

  • Experimental studies highlight the renin-angiotensin system's role in atrial remodeling.
  • Retrospective analyses suggest ACE inhibitors and ARBs may prevent AF onset and recurrence.
  • Current evidence is based on observational data and smaller trials.

Conclusions:

  • The renin-angiotensin system is implicated in hypertension-related atrial remodeling and AF.
  • Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers show promise for AF prevention.
  • Larger prospective trials are needed to confirm the efficacy of these agents in AF prevention.

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