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Related Concept Videos

Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

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Related Experiment Video

Updated: Jun 19, 2026

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
09:53

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Vascular morphogenesis: a Wnt for every vessel?

Claudio Areias Franco1, Stefan Liebner, Holger Gerhardt

  • 1Vascular Biology Laboratory, London Research Institute-Cancer Research UK, 44 Lincoln's Inn Fields, WC2A 3PX London, UK.

Current Opinion in Genetics & Development
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Wnt signaling regulates diverse endothelial cell behaviors during blood vessel development. This review explores how Wnt pathways control cell differentiation, proliferation, and junctions in vascular networks.

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Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Area of Science:

  • Vascular Biology
  • Cell Signaling
  • Developmental Biology

Background:

  • Blood vessel development involves complex coordination of diverse endothelial cell (EC) populations.
  • Endothelial heterogeneity is crucial for organ-specific functions in mature vasculature.
  • Dll4/Notch signaling specifies ECs into tip and stalk cells during sprouting angiogenesis.

Purpose of the Study:

  • To review the molecular mechanisms of Wnt signaling in regulating endothelial cell behavior during vascular development.
  • To highlight the role of Wnt signaling in cell differentiation, proliferation, survival, cell junctions, and polarity.
  • To discuss the interplay between Wnt and Notch signaling in tubulogenesis.

Main Methods:

  • Literature review of recent advances in vascular biology.
  • Analysis of Wnt signaling pathway components and their functions.
  • Synthesis of information on Wnt's role in endothelial cell differentiation and behavior.

Main Results:

  • Wnt signaling is a key regulator of endothelial cell differentiation and function.
  • Wnt pathways influence EC proliferation, survival, cell junctions, and polarity.
  • Wnt signaling coordinates with Notch signaling in branching tubulogenesis.

Conclusions:

  • Wnt signaling plays a critical and multifaceted role in vascular development.
  • Understanding Wnt signaling is essential for comprehending endothelial cell heterogeneity and function.
  • Further research into Wnt pathways can inform therapeutic strategies for vascular diseases.