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Captopril-induced cholestatic jaundice.

M T Hagley1

  • 1Barberton Citizens Hospital, Ohio.

Southern Medical Journal
|January 1, 1991
PubMed
Summary

Captopril can cause cholestatic jaundice, an adverse drug effect. This jaundice resolves after discontinuing captopril treatment, highlighting the need for physician awareness.

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Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • Captopril is frequently prescribed for hypertension and heart failure.
  • Adverse drug reactions necessitate ongoing clinical vigilance.

Observation:

  • A case of cholestatic jaundice was observed in a patient receiving captopril.
  • The jaundice presented as a direct consequence of captopril administration.

Findings:

  • Captopril is identified as the causative agent for cholestatic jaundice in this case.
  • Cessation of captopril therapy led to the resolution of jaundice.

Implications:

  • Physicians must be aware of captopril-induced cholestatic jaundice as a potential adverse effect.
  • Early recognition and drug withdrawal are crucial for managing this condition.