Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pneumatic dilation of cardiac achalasia using low compliance balloon: University-Hospital experience.

Saudi medical journal·2016
Same author

Formol-ether concentration method in the diagnosis of active schistosoma mansoni in patients with detectable IHA.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2009
Same author

Use of serum immunoglobulins G and A for detection of Helicobacter pylori infection in dyspeptic patients by enzyme immunosorbent assay.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2009
Same author

Hepatic granulomas in an arab population: a retrospective study from a teaching hospital in Riyadh.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2009
Same author

Esophageal candidiasis among a dyspeptic population.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2009
Same author

Doxycline-induced esophageal ulcerations.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2009
Same journal

From symptoms to standards: Integrating guidelines, validated tools, and dietary strategies in the care of Arabic-speaking patients with IBS and pelvic floor disorders.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
Same journal

Disease burden of inflammatory bowel disease and subtypes in older adults in 172 high- and middle-income countries: Trends from 2000 to 2023 and projections to 2040.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
Same journal

The unfinished success of hepatitis B control in Saudi Arabia: Concentrated burden in adult males and geographic notification hotspots in the post-vaccination era, 2019-2023.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
Same journal

Association between residential greenness and the risk of inflammatory bowel disease in patients with COVID-19: A Korean nationwide cohort study.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
Same journal

Evaluation of tumor detection capability for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm in each MRI sequence.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
Same journal

Comment on global trends in the burden and quality of care for upper gastrointestinal diseases, 1990-2021.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association·2026
See all related articles

Related Experiment Video

Updated: Jun 19, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Acute pancreatitis.

I A Al Mofleh1

  • 1Department of Medicine, College of Medicine, KSU, Riyadh, Saudi Arabia.

Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Recent advancements in acute pancreatitis research highlight key factors in its pathogenesis, including ischemia and inflammatory mediators. New diagnostic tools and understanding of infections aid in early detection and treatment of this critical condition.

More Related Videos

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
07:10

Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct

Published on: April 1, 2022

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
07:38

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

Published on: May 10, 2024

Area of Science:

  • Gastroenterology and Hepatology
  • Critical Care Medicine

Background:

  • Acute pancreatitis pathogenesis involves ischemia, lysosomal enzymes, free radicals, and inflammatory mediators.
  • Infections in pancreatic necrosis, their transmission, and antibiotic strategies have evolved.
  • Understanding of pancreatic necrosis and multiple organ failure has significantly advanced.

Purpose of the Study:

  • To review recent progress in understanding acute pancreatitis.
  • To highlight advancements in diagnosis, prognosis, and classification.
  • To discuss the role of new diagnostic markers and therapeutic approaches.

Main Methods:

  • Literature review of recent research on acute pancreatitis.
  • Emphasis on etiological factors and pathogenetic mechanisms.
  • Discussion of novel diagnostic and prognostic tools.

Main Results:

  • Inflammatory mediators and cellular byproducts are crucial in pancreatic necrosis.
  • Early diagnosis is facilitated by tests like the rapid urinary trypsinogen-2 test.
  • Biomarkers such as polymorphnuclear elastase, C-reactive protein, and interleukin-6 aid in evaluation.

Conclusions:

  • Advances in understanding pathogenesis, diagnosis, and classification are transforming acute pancreatitis management.
  • New diagnostic tests enable earlier detection and prognosis.
  • Updated knowledge on infection and antibiotics improves therapeutic strategies.