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Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Related Experiment Video

Updated: Jun 19, 2026

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination

Published on: February 18, 2017

Liver regeneration: focus on cell types and topographic differences.

Apostolos N Kandilis¹, John Koskinas, Dina G Tiniakos

¹Laboratory for Experimental Surgery and Surgical Research N.S. Christeas, Medical School of Athens, University of Athens, 15b Ag. Thoma str. GR-115 27 Goudi, Athens, Greece. kandilis_a@med.uoa.gr

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes

|October 30, 2009

Summary

Liver regeneration involves significant cellular changes and regional differences within the hepatic lobule, particularly after partial hepatectomy. Further research is crucial for understanding these mechanisms to improve treatments for liver disease.

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Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Isolation of Regenerating Hepatocytes after Partial Hepatectomy in Mice

Published on: December 2, 2022

Area of Science:

Hepatology
Cellular Biology
Regenerative Medicine

Background:

The liver possesses a significant capacity for regeneration following injury or surgical removal.
Understanding the cellular and regional dynamics of liver regeneration is critical for clinical applications.

Purpose of the Study:

To review the morphological changes at the cellular level during liver regeneration.
To delineate the intralobular differences in the regenerative response after partial hepatectomy.

Main Methods:

A comprehensive review of relevant studies.
Literature search conducted using the Medline database.

Main Results:

Significant alterations between periportal and pericentral regions of the hepatic lobule are observed 24 hours post-hepatectomy.
Hepatocellular proliferation peaks in the periportal areas.
The precise roles of Kupffer cells and the nature of lobule expansion (new lobules vs. increased size) remain areas for further investigation.

Conclusions:

Liver regeneration is a complex process that has been studied extensively.
Further research into the underlying mechanisms of liver regeneration is essential.
Enhanced knowledge can lead to expanded treatment options for patients with liver diseases.