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Related Experiment Video

Updated: Jun 19, 2026

Bioparticle Microarrays for Chemotactic and Molecular Analysis of Human Neutrophil Swarming in vitro

Bioparticle Microarrays for Chemotactic and Molecular Analysis of Human Neutrophil Swarming in vitro

Published on: February 16, 2020

Recent developments and complexities in neutrophil transmigration.

Abigail Woodfin¹, Mathieu-Benoit Voisin, Sussan Nourshargh

¹Queen Mary University of London, William Harvey Research Institute, UK.

Current Opinion in Hematology

|October 30, 2009

Summary

This summary is machine-generated.

Neutrophil transmigration is crucial for innate immunity and inflammatory diseases. Recent research details the cellular and molecular mechanisms governing this process, offering potential targets for anti-inflammatory therapies.

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Area of Science:

Immunology
Cell Biology
Pathophysiology

Background:

Neutrophil migration is vital for innate immunity and inflammatory disease pathogenesis.
Understanding leukocyte biology, particularly neutrophil transmigration, is a dynamic research area.

Purpose of the Study:

This review summarizes recent advancements in neutrophil transmigration mechanisms.
Focuses on the molecular and cellular events facilitating neutrophil movement from blood to inflamed tissues.

Main Methods:

Review of current literature on neutrophil transmigration.
Discussion of cellular and molecular changes in leukocytes and endothelial cells.
Analysis of paracellular and transcellular migration pathways.

Main Results:

Covers prerequisite events like leukocyte crawling and endothelial cell changes.
Details advances in paracellular and transcellular migration, including adhesion molecules.
Examines migration beyond the endothelium, through pericytes and basement membranes.

Conclusions:

Neutrophils play a significant role in inflammatory conditions.
Further understanding of tissue- and stimulus-specific migration mechanisms is needed.
Identifies potential pathways for developing targeted anti-inflammatory interventions.