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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

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Related Experiment Video

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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Ocular circulation in systemic lupus erythematosus.

Monika Modrzejewska1, Lidia Ostanek, Danuta Bobrowska-Snarska

  • 1Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland. monika_modrzej@op.pl

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|October 30, 2009
PubMed
Summary

Systemic lupus erythematosus (SLE) patients show increased retrobulbar vascular resistance. Antiphospholipid antibodies (aPLs) are linked to these elevated resistance indices in ocular vessels.

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Published on: January 12, 2022

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic lupus erythematosus (SLE) is associated with various systemic complications.
  • Ocular involvement in SLE can affect visual function and requires careful monitoring.
  • Retrobulbar hemodynamics may be altered in SLE patients.

Purpose of the Study:

  • To determine mean vascular resistance in retrobulbar arteries of SLE patients.
  • To investigate the statistical relationship between vascular resistance parameters and specific autoantibodies in SLE.
  • To assess the utility of color Doppler imaging (CDI) in evaluating retrobulbar hemodynamics in SLE.

Main Methods:

  • Forty-three SLE female patients and 43 female controls underwent ophthalmic examinations.
  • Immunological markers including ANA, aCL, anti-beta2GPI, LA, and anti-dsDNA antibodies were assessed.
  • Color Doppler imaging (CDI) was used to measure vascular resistance indices (RIs) in the ophthalmic artery (OA), central retinal artery (CRA), and posterior ciliary arteries (PCAs).
  • Statistical analyses included covariance, multiple regression, and various correlation and normality tests.

Main Results:

  • Significantly increased RIs were observed in the OA, CRA, and PCAs of SLE patients compared to controls.
  • Anticardiolipin antibodies (aCL), anti-beta2GPI, and lupus anticoagulant (LAC) showed significant correlation with increased RI in the CRA.
  • SLE diagnosis was significantly correlated with increased RI in the OA and PCAs.
  • Age was also found to be significantly related to RI in the CRA and LPCA.

Conclusions:

  • Color Doppler imaging (CDI) can detect retrobulbar resistance disturbances in SLE patients.
  • Increased resistivity index in ophthalmic and retino-choroidal vessels is associated with SLE diagnosis and the presence of antiphospholipid antibodies (aPLs).
  • These findings highlight potential vascular complications in SLE affecting ocular circulation.