Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

Vaccinations

Vaccinations

Vaccines

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...

What is the Immune System?

What is the Immune System?

Cancer Vaccines

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...

Psychoneuroimmunology: Diabetes and Cancer

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antiphospholipid syndrome in the paediatric population: performance of ACR-EULAR classification criteria in a controlled cohort.

Lupus science & medicine·2026

Same author

Sebetralstat for on-demand treatment of hereditary angioedema: A pooled analysis of placebo-controlled clinical trials.

The World Allergy Organization journal·2026

Same author

[Two Sides of the Same Coin: Eosinophilic Granulomatosis with Polyangiitis or Hypereosinophilic Syndrome - A Case Report].

Harefuah·2026

Same author

Antiphospholipid antibodies among hospitalized patients predict mortality and readmission: A real-world 10-years cohort study.

The American journal of medicine·2026

Same author

Eosinophilia and Risk of Thrombosis and Mortality in Hospitalized Patients: A Retrospective Cohort Study.

Life (Basel, Switzerland)·2026

Same author

Massive Honeybee Envenomation: A Case Series of Simultaneous Multiple Casualties.

The Israel Medical Association journal : IMAJ·2026

Same journal

Joint-specific susceptibility to inflammation is determined in utero.

Nature reviews. Rheumatology·2026

Same journal

Time to rethink the treatment of palindromic rheumatism.

Nature reviews. Rheumatology·2026

Same journal

Sensory nerves protect against tendon degeneration.

Nature reviews. Rheumatology·2026

Same journal

Publisher Correction: TLR7 in systemic lupus erythematosus: genetics and emerging therapies.

Nature reviews. Rheumatology·2026

Same journal

TLR7 in systemic lupus erythematosus: genetics and emerging therapies.

Nature reviews. Rheumatology·2026

Same journal

Lung disease in rheumatoid arthritis.

Nature reviews. Rheumatology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Vaccines and autoimmunity.

Nancy Agmon-Levin¹, Ziv Paz, Eitan Israeli

¹Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Sheba Medical Center, Tel-Hashomer 52621, Israel.

Nature Reviews. Rheumatology

|October 30, 2009

Summary

This summary is machine-generated.

Vaccines prevent infections but can rarely trigger autoimmune diseases in healthy individuals. Establishing a direct link between vaccines and autoimmunity is challenging due to rare, delayed reactions.

More Related Videos

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Related Experiment Videos

Last Updated: Jun 19, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Area of Science:

Immunology
Vaccinology
Autoimmunity

Background:

Vaccines are crucial for preventing infectious diseases.
Adverse events from vaccines are a concern, especially as they are given to healthy people.
While most vaccine side effects are mild, rare severe reactions like autoimmunity can occur.

Purpose of the Study:

To discuss the relationship between vaccines and autoimmune phenomena.
To explore the mechanisms by which vaccines might induce autoimmunity.
To review the challenges in establishing causality for post-vaccination autoimmunity.

Main Methods:

Review of published scientific evidence.
Analysis of expert experience.
Discussion of temporal and causal interactions.

Main Results:

Vaccine-induced autoimmunity is rare, with a latency period ranging from days to years.
Ascertaining causality is difficult due to the rarity and subacute presentation of these events.
Various vaccine components may potentially trigger autoimmune responses.

Conclusions:

Understanding the complex interplay between vaccines and autoimmunity is essential.
Further research is needed to elucidate the mechanisms and improve the safety profile of vaccines.
While rare, the potential for vaccines to induce autoimmunity warrants careful consideration and investigation.