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Related Experiment Videos

Chemical peritonitis secondary to intraperitoneal vancomycin.

D I Charney1, S F Gouge

  • 1Department of Medicine, Brooke Army Medical Center, San Antonio, TX 78234-6200.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|January 1, 1991
PubMed
Summary

Chemical peritonitis from intraperitoneal vancomycin in peritoneal dialysis patients can occur. Differences in vancomycin preparation impurities may explain these sterile peritonitis episodes.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Sterile peritonitis associated with intraperitoneal vancomycin in peritoneal dialysis (PD) patients is controversial.
  • Previous reports suggested brand-specific vancomycin preparations might be implicated.

Observation:

  • Four episodes of sterile peritonitis were observed in three PD patients receiving intraperitoneal vancomycin.
  • These episodes occurred after switching from Vancocin to a generic vancomycin preparation.

Findings:

  • High-performance liquid chromatography (HPLC) revealed Vancocin had fewer impurities than the generic preparation.
  • Impurities in non-Vancocin vancomycin preparations may contribute to chemical peritonitis.

Implications:

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  • This study supports the occurrence of chemical peritonitis due to intraperitoneal vancomycin.
  • Increased clinical awareness is needed to identify and manage these adverse events in PD patients.