Related Experiment Video
Updated: Jun 19, 2026
Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
Published on: April 7, 2023
Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with
Ozge Uner Ayvaz1, Abdullah Ekmekçi, Volkan Baltaci
1Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, 06500 Ankara, Turkey. ozg_e@yahoo.com
Purpose:
Association of ESR1 gene PvuII, XbaI and (TA)n microsatellite polymorphisms and woman infertility was evaluated.
Methods:
Infertile(n = 104) and fertile(n = 107) women were included in this study. We performed polymerase chain reaction-restriction fragment-length polymorphism analysis for detecting ESR1 polymorphisms.
Result(S):
PvuII and XbaI polymorphisms confered risk for infertility in a simple dominant manner in which a significant relationship was observed between infertile and control women. Infertile women had fewer(<18) short repeat alleles in promotor region. ESR1 genotypes were compared concerning maturation, fertilization, pregnancy rates and embryo quality. Although no difference was found in terms of pregnancy rates, maturation and fertilization rates were significantly smaller in pp and xx genotypes. Also, pp genotypes had significantly lower number of good quality embryos. Long TA repeat in promotor was found to be associated with low fertilization rate.
Conclusion(S):
Polymorphisms at the ESR1 gene are associated with infertility in this Turkish infertile women population.
Related Concept Videos
01:24In Vitro Fertilization
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
02:07Oogenesis
01:28Infertility in Females
Endometriosis, a condition characterized by abnormal growth of endometrial...