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Presenting manifestations of eosinophilic cystitis in two Filipino children
Paul Joseph T Galutira1, Beatrice B Canonigo, Ma Rosario F Cabansag
1Section of Pediatric Nephrology, University of Santo Tomas Hospital, Manila, Philippines. pj_7611@yahoo.com
Insights
Eosinophilic cystitis, a rare pediatric condition, presents with urinary issues and blood. Treatment with corticosteroids led to symptom resolution in two Filipino children.
Area of Science:
- Pediatric Urology
- Nephrology
- Pathology
Background:
- Eosinophilic cystitis is an extremely rare condition in children.
- It is characterized by eosinophilic infiltration of the bladder wall.
Observation:
- Two Filipino children presented with irritative voiding symptoms, gross hematuria, and peripheral eosinophilia.
- Imaging revealed hydroureteronephrosis and bladder wall thickening.
- Diagnosis was confirmed via cystoscopy and transurethral biopsy.
Findings:
- Both patients received corticosteroid therapy, with one also receiving an antihistamine.
- Complete resolution of signs and symptoms was observed in both cases.
- Follow-up imaging showed normalization of hydroureteronephrosis and bladder wall thickness.
Implications:
- Corticosteroids appear effective in treating pediatric eosinophilic cystitis.
- Early diagnosis and prompt treatment can lead to favorable outcomes.
- This case report highlights the importance of considering rare diagnoses in pediatric urological conditions.
Abstract:
Eosinophilic cystitis is a very rare clinical disease entity in the pediatric population. We report two cases of Filipino children with eosinophilic cystitis who presented with irritative voiding symptoms, gross hematuria, peripheral eosinophilia, and hydroureteronephrosis and urinary bladder wall thickening visualized on ultrasonography and CT urography. Cystoscopy and transurethral biopsy confirmed the diagnosis. Both patients were started with corticosteroid with or without an antihistamine. Resolution from the signs and symptoms were observed in both patients as documented by disappearance of peripheral eosinophilia, normal urinalysis results, and resolution of the hydroureteronephrosis and urinary bladder wall thickening on ultrasonography on follow-up.
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