Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Preparation and Analysis of Histological Slides of Rat and Mouse Eyeballs to Evaluate the Retina

Preparation and Analysis of Histological Slides of Rat and Mouse Eyeballs to Evaluate the Retina

Published on: August 23, 2024

THE FINE STRUCTURE OF THE PIGMENT EPITHELIUM IN THE ALBINO RAT.

J E Dowling¹, I R Gibbons

¹Biological Laboratories, Harvard University, Cambridge, Massachusetts.

The Journal of Cell Biology

|October 30, 2009

Summary

Researchers studied pigment epithelial cell inclusion bodies, finding they vary in size and structure. These bodies, potentially related to lysosomes, show transitional stages from granular to lamellar forms, possibly linked to rod outer segments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A study of the reactivity of S<sup>(VI)</sup>-F containing warheads with nucleophilic amino-acid side chains under physiological conditions.

Organic & biomolecular chemistry·2017

Same author

Dopaminergic mechanisms in the carp retina: Effects of dopamine, K(+) and light on cyclic AMP synthesis.

Neurochemistry international·2010

Same author

Rotational matched spatial filter for biological pattern recognition.

Applied optics·2010

Same author

AN EFFECT OF ADENOSINE TRIPHOSPHATE ON THE LIGHT SCATTERED BY SUSPENSIONS OF CILIA.

The Journal of cell biology·2009

Same author

Some properties of the protein forming the outer fibers of cilia.

The Journal of cell biology·2009

Same author

Some properties of the protein forming the outer fibers of cilia.

The Journal of cell biology·2009

Area of Science:

Cell biology
Ophthalmology

Background:

Pigment epithelial cells are crucial for retinal health.
Inclusion bodies within these cells are not well understood.

Purpose of the Study:

To characterize the morphology and potential origin of inclusion bodies in the pigment epithelial cell.
To investigate the relationship between these inclusion bodies and retinal structures.

Main Methods:

Microscopic examination of pigment epithelial cells.
Morphological analysis of inclusion bodies at varying sizes.

Main Results:

Inclusion bodies exhibit a range of sizes (0.4 to 2 micrometers) and forms.
Smallest bodies are granular with a membrane, resembling lysosomes.

More Related Videos

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

Published on: February 27, 2011

A Simplified Method for Isolation and Culture of Retinal Pigment Epithelial Cells from Adult Mice

A Simplified Method for Isolation and Culture of Retinal Pigment Epithelial Cells from Adult Mice

Published on: May 24, 2024

Related Experiment Videos

Last Updated: Jun 19, 2026

Preparation and Analysis of Histological Slides of Rat and Mouse Eyeballs to Evaluate the Retina

Preparation and Analysis of Histological Slides of Rat and Mouse Eyeballs to Evaluate the Retina

Published on: August 23, 2024

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

Dissection of a Mouse Eye for a Whole Mount of the Retinal Pigment Epithelium

Published on: February 27, 2011

A Simplified Method for Isolation and Culture of Retinal Pigment Epithelial Cells from Adult Mice

A Simplified Method for Isolation and Culture of Retinal Pigment Epithelial Cells from Adult Mice

Published on: May 24, 2024

Largest bodies are predominantly lamellar, with transitional forms observed.

Conclusions:

The observed morphological continuum suggests a developmental relationship between granular and lamellar inclusion bodies.
The lamellar inclusion bodies may be related to rod outer segments, warranting further investigation.