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THE OCCURRENCE AND STRUCTURE OF MICROBODIES : A Comparative Study.

B A Afzelius1

  • 1Wenner-Gren Institute, University of Stockholm, Stockholm, Sweden.

The Journal of Cell Biology
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Microbodies with a specific inclusion, termed "uricosomes," are found in species with the enzyme uricase, such as rats and dogs. Chickens and humans, lacking uricase, do not have these specialized microbodies.

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Area of Science:

  • Cell Biology
  • Biochemistry
  • Comparative Anatomy

Background:

  • Microbodies are organelles found in eukaryotic cells.
  • The presence and function of microbodies, particularly in relation to specific enzymes, are areas of ongoing research.
  • Uricase is an enzyme involved in purine metabolism.

Purpose of the Study:

  • To investigate the correlation between the presence of microbodies with a characteristic inclusion and the enzyme uricase across different species.
  • To determine if a specific type of microbody inclusion is consistently associated with uricase activity.
  • To propose a standardized term for microbodies exhibiting this inclusion.

Main Methods:

  • Electron microscopy was used to examine liver tissues from various species: chickens, rats, mongrel dogs, Dalmatian dogs, and humans.
  • Microbodies within these liver cells were analyzed for the presence and structural characteristics of their inclusions.
  • Enzyme content, specifically uricase, was considered in relation to observed microbody morphology.

Main Results:

  • Microbodies with a distinct inclusion were identified in the livers of rats and mongrel dogs.
  • Dalmatian dogs also exhibited these microbodies, though the inclusion was generally smaller.
  • Chickens and humans lacked both the enzyme uricase and the observed microbody inclusion.

Conclusions:

  • There is a positive correlation between the presence of uricase and microbodies containing a specific type of inclusion.
  • The term "uricosome" is proposed for microbodies with the described inclusion, highlighting their association with uricase.
  • This finding contributes to understanding the functional and structural diversity of microbodies across species.