TWO CASES OF SARCOMATOSIS WITH PURPURA HAEMORRHAGICA.

Area of Science:

• Pathology
• Oncology
• Vascular Medicine

Background:

• Purpura can accompany sarcomatosis, suggesting complex underlying mechanisms.
• Previous literature suggests embolic origins for some purpuric conditions, often associated with other diseases.

Purpose of the Study:

• To explain the purpura observed in two cases of sarcomatosis.
• To elucidate the role of vascular involvement and systemic factors in purpura development.

Main Methods:

• Histological examination of affected tissues, including vessel walls and cutaneous nodules.
• Analysis of clinical presentation, including fever, cachexia, and asthenia.
• Review of existing literature on embolic purpura and sarcomatosis.

Main Results:

• Sarcoma cells directly invaded vessel walls and perivascular lymphatics.
• Emboli of sarcoma cells occluded blood vessel lumina, leading to hemorrhages.
• Systemic factors like cachexia and altered blood composition contributed to extensive hemorrhages.

Conclusions:

• Purpura in sarcomatosis is multifactorial, involving direct vascular invasion, emboli, and systemic patient conditions.
• Cutaneous nodules were primarily hemorrhagic or necrotic, not pure sarcomatous metastases.
• The findings support an analogy to embolic infarcts, with compromised vascular integrity leading to hemorrhage.