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Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Urine Studies I: Urinalysis01:29

Urine Studies I: Urinalysis

Urinalysis is a widely used diagnostic test that analyzes urine's physical, chemical, and microscopic characteristics. Healthcare providers use it to detect and monitor various health conditions, including renal disease, urinary tract infections (UTIs), diabetes, and metabolic or systemic disorders.Components of UrinalysisUrinalysis consists of three primary components: physical, chemical, and microscopic examination. Each provides unique insights into the urine sample and, by extension, the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Applications of a simultaneous atomic emission mass spectral gas chromatography detector in drug analysis.

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Related Experiment Video

Updated: Jun 19, 2026

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

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OBSERVATIONS ON A CASE OF CYCLIC ALBUMINURIA.

L B Mendel1, D B Hooker

  • 1Sheffield Laboratory of Physiological Chemistry, Yale University.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

This study reports cyclic albuminuria in a healthy young man. Albuminuria resolved when the patient adopted a horizontal posture, suggesting circulatory changes in the kidneys.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Urology

Background:

  • Cyclic albuminuria is a rare condition characterized by intermittent protein excretion in urine.
  • Understanding the triggers and resolution of albuminuria is crucial for diagnosing kidney conditions.

Purpose of the Study:

  • To document a novel case of cyclic albuminuria in an otherwise healthy individual.
  • To investigate the relationship between diet, physical activity, posture, and albuminuria.

Main Methods:

  • Observational case study.
  • Monitoring of urinary protein excretion over time.
  • Correlation analysis with diet, muscular work, and body posture.

Main Results:

  • Cyclic albuminuria was observed in a young, healthy male.

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  • Protein excretion showed no correlation with diet or muscular work.
  • A significant decrease in albuminuria was noted in the horizontal posture.
  • No clear relationship was found between urine volume and protein excretion.
  • Conclusions:

    • The horizontal posture appears to resolve albuminuria in this case.
    • Kidney circulatory changes are a potential, though speculative, explanation for the observed phenomenon.
    • Further research is needed to elucidate the mechanisms behind posture-dependent albuminuria.