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Fibrous Proteins

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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...

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Related Experiment Video

Updated: Jun 19, 2026

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction

Observing and Quantifying Fibroblast-mediated Fibrin Gel Compaction

Published on: January 16, 2014

A STUDY OF EPIDERMAL FIBRILS.

¹Pathological Laboratory, St. Louis University Medical Department.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Human epidermis shows prominent fibrils in the stratum germinativum during increased cell activity, correlating with cell production rates. These findings suggest a unified view of fibril development in epithelial tissues.

Area of Science:

Dermatology
Cell Biology
Histology

Background:

Human epidermis normally contains protoplasmic fibrils in the stratum filamentosum.
Well-developed fibrils are observed in the stratum germinativum of certain animal species.

Purpose of the Study:

To investigate the presence and significance of fibrils in the human stratum germinativum.
To understand the relationship between fibril development and cell activity in human epidermis.

Main Methods:

Microscopic examination of human epidermis under varying conditions.
Observation of fibril differentiation and cell production rates.

Main Results:

Fibrils in the human stratum germinativum appear under conditions of increased cell activity.

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The prominence of these fibrils is directly proportional to the rate of cell production.

Differentiation of stratum germinativum fibrils into stratum filamentosum fibrils is observable.

Conclusions:

A unified classification of epidermal fibrils is proposed, based on their developmental process.
Epidermal fibril production is analogous to that in other cell types under similar conditions.
These findings may aid in classifying epithelial neoplasms.