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Updated: Jun 19, 2026
08:04
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
Published on: June 11, 2019
THE HUMAN SPLEEN AS AN HAEMATOPLASTIC ORGAN, AS EXEMPLIFIED IN A CASE OF SPLENOMEGALY WITH SCLEROSIS OF THE
1Ayer Clinical Laboratory, Pennsylvania Hospital.
The Journal of Experimental Medicine
|October 30, 2009
Abstract:
1. The nodules found in the spleen are islands of active haematoplastic tissue. 2. The bone-marrow, at least in the case which has been described, has been the primary focus of disease; some toxin has probably produced a chronic inflammatory change. 3. The bone-marrow, owing to its enormous sclerosis, has lost its haemopoëtic powers totally or to a marked degree and the spleen has reverted to its foetal power to form blood.
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