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Published on: September 1, 2016

THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. ACUTE

B Benacerraf1, J L Potter, R T McCluskey

  • 1Department of Pathology, New York University-Bellevue Medical Center, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen. These findings are compared with those reported in rats injected with anti-kidney serum.

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