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Updated: Jun 19, 2026
Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
STUDIES ON ANTIBODY PRODUCTION : VI. THE COURSE, SENSITIVITY, AND HISTOLOGY OF THE SECONDARY RESPONSE IN VITRO
T F O'Brien1, M C Michaelides, A H Coons
1Department of Bacteriology and Immunology, Harvard Medical School, Boston.
Abstract:
The in vitro anamnestic antibody response of popliteal lymph node fragments to additions of antigen closely resembles the in vivo anamnestic antibody response in its sensitivity to antigen, in the time course of antibody production, and in the sequence of appearance and the morphology of the antibody containing cells. Most of the cells responsible for antibody synthesis remain in the explant and do not migrate, although a few can be found in the outgrowing sheet of cells. The smallest concentration of bovine serum albumin which stimulates an anamnestic response in vitro is about 1 x 10(-9) gm/ml.
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