Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rabies

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The social formation of fitness: lifetime consequences of prenatal nutrition and postnatal care in a wild mammal population.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2023

Same author

A veil of ignorance can promote fairness in a mammal society.

Nature communications·2021

Same author

Demographic histories and genetic diversity across pinnipeds are shaped by human exploitation, ecology and life-history.

Nature communications·2018

Same author

Kin discrimination via odour in the cooperatively breeding banded mongoose.

Royal Society open science·2018

Same author

Pregnancy is detected via odour in a wild cooperative breeder.

Biology letters·2017

Same author

Rat eradication comes within a whisker! A case study of a failed project from the South Pacific.

Royal Society open science·2016

Same journal

Retraction: In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.

The Journal of experimental medicine·2026

Same journal

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.

The Journal of experimental medicine·2026

Same journal

Flawed translation triggers oncogenic B-T cell communication.

The Journal of experimental medicine·2026

Same journal

Correction: LCK'ed in: Inborn errors of immunity in LCK reveal how TCR signaling is calibrated.

The Journal of experimental medicine·2026

Same journal

Mechanobiology of inflammation: Pulling the strings of innate immunity.

The Journal of experimental medicine·2026

Same journal

Bile acid retention in efferocytic macrophages shapes their inflammatory status during cholangitis.

The Journal of experimental medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

A Laboratory Method to Measure Contagious Yawning in Rats

A Laboratory Method to Measure Contagious Yawning in Rats

Published on: June 14, 2019

EXPERIMENTAL YAWS IN THE MONKEY AND RABBIT.

¹Laboratories of the Rockefeller Institute for Medical Research, New York.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Rabbits experimentally infected with yaws and syphilis spirochetes developed testicular lesions and positive complement fixation reactions. This model allows for further study of cultivation, immunity, and treatment for these diseases.

More Related Videos

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

Related Experiment Videos

Last Updated: Jun 19, 2026

A Laboratory Method to Measure Contagious Yawning in Rats

A Laboratory Method to Measure Contagious Yawning in Rats

Published on: June 14, 2019

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Behavioral Assessment of Manual Dexterity in Non-Human Primates

Published on: November 11, 2011

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits

Published on: March 27, 2021

Area of Science:

Medical Microbiology
Immunology
Veterinary Pathology

Background:

Syphilis and yaws are caused by distinct spirochetes.
Animal models are crucial for studying infectious diseases.

Purpose of the Study:

To establish a rabbit testicular infection model for yaws and syphilis spirochetes.
To investigate the pathological and immunological responses in infected rabbits.

Main Methods:

Inoculation of rabbit testicles with yaws and syphilis spirochetes.
Serial passage of infection through successive generations.
Histopathological examination of testicular lesions.
Complement fixation tests to assess immune response.

Main Results:

Successful infection and sustained transmission of both yaws and syphilis spirochetes in rabbit testicles.
Development of testicular enlargement and nodules, characterized by tubular necrosis and inflammation.
Positive complement fixation reactions observed in rabbits infected with both pathogens.

Conclusions:

Rabbit testicular infection with yaws and syphilis spirochetes provides a viable model for research.
This model facilitates investigations into spirochete cultivation, host immunity, and therapeutic interventions.