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STUDIES ON FERMENT ACTION : III. A SPECIFIC IMMUNE LIPASE.

J W Jobling¹, C G Bull

¹Nelson Morris Institute for Medical Research, Chicago.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Erythrocytes contain unique lipids that act as antigens. Immunization increases serum lipase, which plays a role in specific red blood cell lysis during immune responses.

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Area of Science:

Immunology
Biochemistry
Hematology

Background:

Erythrocytes possess species-specific lipoidal constituents and combinations.
Lipoids and their combinations can function as specific antigens.

Purpose of the Study:

To investigate the specificity of serum lipase increase following immunization with foreign erythrocytes.
To elucidate the role of specific serum lipase in hemolyses.

Main Methods:

Immunization of animals with foreign red blood cells.
Measurement of serum lipase activity.
Analysis of lipase activity in relation to specific immune responses.

Main Results:

A species-specific increase in serum lipase was observed upon immunization with foreign erythrocytes.
This lipase increase was found to be, at least partially, specific to the immunization agent.

Conclusions:

Specific lipoidal antigens on erythrocytes elicit a specific immune response involving serum lipase.
The identified specific lipase is implicated as a key factor in the mechanism of specific serum hemolyses.