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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Updated: Jun 19, 2026

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
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PANCREATIC TRANSPLANTATIONS IN THE SPLEEN.

J H Pratt1, F T Murphy

  • 1Laboratory of the Theory and Practice of Physic, Harvard University, Boston.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary

Pancreatic tissue can survive in the spleen for months after transplantation. Isolated pancreatic acini prevented diabetes, but complete pancreatic extirpation led to death within 187 days.

Area of Science:

  • Endocrinology
  • Surgical Research

Background:

  • The pancreas plays a vital role in metabolic regulation.
  • Understanding pancreatic tissue viability and function post-transplantation is crucial for metabolic research.

Purpose of the Study:

  • To investigate the viability and function of pancreatic tissue after autotransplantation to the spleen.
  • To determine the impact of isolated pancreatic acini on diabetes development.

Main Methods:

  • Autotransplantation of pancreatic tissue into the spleen in an animal model.
  • Separation of the implanted tissue from original vascular and nervous connections.
  • Observation of tissue survival and metabolic status.

Main Results:

  • Implanted pancreatic tissue survived and functioned for several months.

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  • A small nodule of pancreatic acini, lacking Islets of Langerhans, prevented diabetes onset.
  • Animals died 187 days post-pancreatectomy, indicating the necessity of the entire pancreas.

    • Conclusions:

    • Pancreatic tissue can maintain viability and function in an ectopic splenic environment.
    • Islets of Langerhans are essential for preventing diabetes, while acinar tissue alone does not suffice.
    • Complete pancreatic extirpation is ultimately fatal, highlighting the pancreas's indispensable role.