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Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...
Botulism01:22

Botulism

Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
Tetanus01:29

Tetanus

Tetanus is a life-threatening neurological disorder characterized by persistent muscle contractions and spastic paralysis. It is caused by Clostridium tetani, a motile, Gram-positive, rod-shaped, obligate anaerobe. These bacteria produce terminal endospores, giving them a distinctive “lollipop” or “tennis-racket” appearance. They thrive in anaerobic environments, such as those found in deep puncture wounds.Once introduced into the body, the spores germinate into vegetative cells. These cells...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

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Whole Body Vibration Methods with Survivors of Polio
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Whole Body Vibration Methods with Survivors of Polio

Published on: October 17, 2018

PARALYSIS IN A DOG SIMULATING POLIOMYELITIS.

S Flexner1, P F Clark

  • 1Laboratories of The Rockefeller Institute for Medical Research, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

A dog experienced paralysis similar to poliomyelitis. Autopsy revealed spinal cord lesions, but attempts to transmit the disease to other animals failed, suggesting a non-infectious cause.

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Area of Science:

  • Veterinary Neurology
  • Comparative Pathology

Background:

  • Poliomyelitis, a viral disease, causes paralysis in humans.
  • Canine paralysis can mimic neurological conditions seen in other species.

Purpose of the Study:

  • To investigate a case of paralysis in a pet dog that resembled poliomyelitis.
  • To determine the pathological basis and potential infectious nature of the canine paralysis.

Main Methods:

  • Clinical observation of a paralyzed pet dog.
  • Post-mortem examination (autopsy) of the dog's central nervous system.
  • Intracerebral inoculation of spinal cord homogenate into susceptible animal models (dogs and monkeys).

Main Results:

  • The dog exhibited paralysis clinically similar to human poliomyelitis.
  • Autopsy revealed pathological changes in the spinal cord and intervertebral ganglia.
  • Inoculation studies did not induce paralysis or disease symptoms in recipient dogs or monkeys.

Conclusions:

  • The observed canine paralysis shared features with poliomyelitis but had distinct neuropathological findings.
  • The failure of transmission suggests the condition was not caused by a poliovirus-like agent.
  • Further investigation is needed to identify the etiology of this specific canine paralysis.