Related Experiment Video
Updated: Jun 19, 2026
10:22
Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
Published on: December 4, 2015
MALARIAL PIGMENT (HEMATIN) AS AN ACTIVE FACTOR IN THE PRODUCTION OF THE BLOOD PICTURE OF MALARIA
1Pharmacological Laboratory of the University of Wisconsin, Madison, and the Pathological Laboratory of the University of North Carolina, Chapel Hill.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Alkaline hematin injections cause dose-dependent anemia and affect blood components in rabbits. Hematin
Area of Science:
- Hematology
- Toxicology
- Pathophysiology
Background:
- Alkaline hematin is a derivative of heme.
- Hematin is implicated in various pathological conditions.
Purpose of the Study:
- To investigate the hematological effects of alkaline hematin administration in rabbits.
- To understand the toxicological impact of hematin on blood parameters.
Main Methods:
- Intravenous injections of alkaline hematin were administered to rabbits.
- Hematological parameters including red blood cells, white blood cells, platelets, coagulation, and bleeding times were analyzed.
Main Results:
- Dose-dependent anemia was observed, proportional to hematin amount and animal susceptibility.
- Hematin intoxication led to increased leukocytes with a high percentage of mononuclear cells and pigmented phagocytes.
- Platelet destruction was noted, resulting in prolonged blood coagulation and bleeding times.
- Hemoglobinemia was an occasional finding.
Conclusions:
- Alkaline hematin induces significant hematological alterations in rabbits.
- The observed effects, including anemia, leukocytosis, thrombocytopenia, and coagulation disturbances, are linked to hematin.
- These findings suggest hematin's role in pathological conditions like malaria.
More Related Videos
10:50Detection and Quantification of Plasmodium falciparum in Aqueous Red Blood Cells by Attenuated Total Reflection Infrared Spectroscopy and Multivariate Data Analysis
Published on: November 2, 2018
07:27A Simple Protocol for Platelet-mediated Clumping of Plasmodium falciparum-infected Erythrocytes in a Resource Poor Setting
Published on: May 16, 2013
Related Concept Videos
01:29Malaria
Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
01:19Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
00:58Symbiosis
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
01:24Hemoglobin
Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
01:19Rh Blood Group
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
01:21Antiprotozoal Agents
Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...