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A NOTE ON THE FATE OF TARTRATES IN THE BODY
F P Underhill1, H G Wells, S Goldschmidt
1Sheffield Laboratory of Physiological Chemistry of Yale University, New Haven, and the Pathological Laboratory of the University of Chicago, Chicago.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Sodium tartrate injected into rabbits did not appear in urine. This suggests the salt damages kidney tubules, preventing its excretion, with no compensatory kidney function observed.
Area of Science:
- Nephrology
- Toxicology
- Renal Physiology
Background:
- Sodium tartrate is a chemical compound with known physiological effects.
- Understanding renal excretion pathways is crucial for toxicology and pharmacology.
- Kidney tubule and glomerular functions are key determinants of substance elimination.
Purpose of the Study:
- To investigate the renal excretion of sodium tartrate in rabbits.
- To determine the mechanism behind the absence of sodium tartrate in urine.
- To assess the role of kidney tubules and glomeruli in sodium tartrate handling.
Main Methods:
- Subcutaneous administration of sodium tartrate to rabbits.
- Urine analysis to detect the presence of sodium tartrate.
- Histological examination of kidney tissues (implied).
Main Results:
- Sodium tartrate administered subcutaneously was not detected in the urine of rabbits.
- The convoluted tubules showed signs of damage or disintegration.
- No compensatory increase in glomerular filtration was observed.
Conclusions:
- The disintegration of convoluted tubules by sodium tartrate prevents its urinary excretion.
- Glomerular function does not compensate for the impaired tubular elimination of sodium tartrate.
- Sodium tartrate exhibits nephrotoxic effects on renal tubules.
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