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Published on: May 6, 2018
A NOTE ON NITROGEN RETENTION FOLLOWING REPEATED INJECTIONS OF NEPHROTOXIC AGENTS
1Laboratory of Pathology (Phillips Fund) and the Laboratory of Biological Chemistry of the Harvard Medical School, Boston.
Abstract:
It is possible by means of repeated injections of uranium nitrate to produce in the cat a subacute or chronic nephritis which can progress to a fatal termination and show in its course increasing accumulation of non-protein nitrogen in the blood. This nephritis differs only slightly from the spontaneous chronic nephritis of the species. Repeated doses of diphtheria toxin produce a subacute form of nephritis with only temporary or slight retention, but nevertheless anatomically a well defined nephritis. The spontaneous nephritis studied resembles more closely that produced by uranium nitrate than that produced by diphtheria toxin both histologically and from the standpoint of blood analysis.
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