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The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
ON CERTAIN SPONTANEOUS CHICKEN TUMORS AS MANIFESTATIONS OF A SINGLE DISEASE : I. SPINDLE-CELLED SARCOMATA RIFTED WITH
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Two distinct chicken tumors, when transplanted, produced identical neoplasms. These findings suggest that different chicken tumor types may arise from a single etiological agent, simplifying cancer research.
Area of Science:
- Oncology
- Virology
- Comparative Pathology
Background:
- Spontaneous chicken tumors exhibit diverse characteristics.
- Transplantation of these tumors can lead to the development of new neoplasms.
Purpose of the Study:
- To investigate the relationship between spontaneous chicken tumors and their transplanted counterparts.
- To determine if different tumor types share a common etiological agent.
Main Methods:
- Transplantation of two distinct spontaneous chicken tumors (No. 18 and No. 38).
- Characterization of the resulting transplanted neoplasms' growth, metastatic patterns, and histological structure.
- Assessment of the filterable agents responsible for tumor induction, including their stability and infectivity.
Main Results:
- Both spontaneous tumors, despite initial differences, yielded identical transplanted neoplasms.
- Transplanted tumors showed slow growth, metastasized to skeletal muscle, and exhibited variable histological features.
- Both tumors were caused by filterable agents, with strain differences noted in agent stability and infectivity.
Conclusions:
- The two spontaneous chicken tumors, and their resulting transplanted neoplasms, are likely caused by different strains of a single etiological agent.
- This finding simplifies the etiological problem of chicken tumors, suggesting a common underlying cause for various tumor types.
- Further comparative studies are needed to confirm the universality of a single agent for diverse spontaneous chicken tumors.
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