LIPOIDS AS INHIBITORS OF ANAPHYLACTIC SHOCK : STUDIES ON FERMENT ACTION. XVIII

Area of Science:

• Immunology
• Biochemistry

Background:

• Anaphylactic shock is a severe allergic reaction.
• The role of serum antitryptic activity in anaphylaxis is not fully understood.

Purpose of the Study:

• To investigate the effect of serum lipoids and egg yolk lipoids on antitryptic titer.
• To determine the influence of these lipoids on immunity to anaphylactic shock.
• To explore the impact of antigen lipoid extraction and co-administered substances on anaphylaxis.

Main Methods:

• Subcutaneous injections of serum lipoids and egg yolk lipoids.
• Administration of antigens (purified horse serum albumen) with and without lipoid extraction.
• Simultaneous injection of antigens with sublethal doses of soap solutions.
• Assessment of relative immunity to acute anaphylactic shock.

Main Results:

• Injections of serum lipoids and egg yolk lipoids increased serum antitryptic titer.
• Injected animals exhibited relative immunity to anaphylactic shock.
• Lipoid extraction from antigens enhanced their toxicity in sensitized animals.
• Soap solutions prevented anaphylactic shock when co-administered with antigen.
• A refractory state post-anaphylactic shock correlated with increased antitryptic titer.

Conclusions:

• Serum lipoids and egg yolk lipoids can elevate antitryptic titer and confer resistance to anaphylaxis.
• Antigen modification (lipoid extraction) can alter its anaphylactogenic potential.
• Certain co-administered substances can mitigate anaphylactic reactions.
• Increased serum antitryptic titer is a contributing factor to the refractory state after anaphylactic shock.