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SERUM FERMENTS AND ANTIFERMENT AFTER FEEDING : STUDIES ON FERMENT ACTION. XXI
J W Jobling1, W Petersen, A A Eggstein
1Department of Pathology, Medical Department, Vanderbilt University, Nashville.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Post-feeding, serum non-coagulable nitrogen rises, peaking in six hours, primarily due to increased amino acids in portal blood. Serum protease levels typically decrease, while lipase activity shows a transient increase.
Area of Science:
- Biochemistry
- Physiology
Background:
- Dietary intake significantly impacts metabolic processes.
- Understanding postprandial changes in blood composition is crucial for metabolic research.
Purpose of the Study:
- To investigate the biochemical changes in serum and portal blood following a meal.
- To quantify alterations in non-coagulable nitrogen, amino acids, proteoses, protease, antiferment, and lipase.
Main Methods:
- Blood samples were analyzed at various time points after feeding.
- Measurements included non-coagulable nitrogen, amino acids, proteoses, protease activity, antiferment levels, and lipase activity.
- Comparisons were made between portal and systemic circulation.
Main Results:
- Serum non-coagulable nitrogen increased post-feeding, peaking at six hours, with the greatest increase observed in portal blood due to elevated amino acids.
- Serum protease activity generally decreased, reaching a minimum between five and seven hours post-feeding.
- Serum lipase (esterase) activity showed a slight increase, peaking at three hours, with the lowest concentrations typically found in hepatic blood.
Conclusions:
- Feeding induces significant, time-dependent changes in serum and portal blood biochemistry.
- Amino acid absorption is a key factor in postprandial non-coagulable nitrogen elevation.
- Protease and lipase activities exhibit distinct patterns following nutrient intake.
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