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INTESTINAL OBSTRUCTION : V. PROTEOSE INTOXICATION.
G H Whipple1, F H Rodenbaugh, A R Kilgore
1George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Toxic proteoses accumulating in closed intestinal loops cause intoxication. This primary proteose, resistant to digestion, leads to symptoms mimicking intestinal obstruction in dogs.
Area of Science:
- Gastroenterology
- Toxicology
- Biochemistry
Background:
- Intestinal obstruction leads to intoxication due to toxic material accumulation in closed loops.
- Previous evidence suggests a specific 'loop poison' is responsible for this intoxication.
Purpose of the Study:
- To identify the toxic substance responsible for intoxication in closed intestinal loops.
- To characterize the properties of this toxic substance and its effects.
Main Methods:
- Chemical analysis of the contents of closed intestinal loops.
- Experimental intoxication of dogs with isolated toxic substances.
- Autopsy and blood analysis of affected dogs.
Main Results:
- A toxic substance, resistant to digestion and soluble in water, was identified.
- This substance, isolated as primary proteoses, caused symptoms identical to intestinal loop intoxication in dogs.
- Autopsy revealed splanchnic paralysis and organ engorgement, with blood changes including concentration and incoagulability.
Conclusions:
- Experimental evidence points to a primary proteose as the essential toxic agent in closed intestinal loops and intestinal obstruction.
- This toxic proteose is likely excreted by the kidneys, potentially explaining clinical improvement after transfusion.
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