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Ileectomy-induced Bile Overaccumulation in Mouse Intestine

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INTESTINAL OBSTRUCTION : V. PROTEOSE INTOXICATION.

G H Whipple¹, F H Rodenbaugh, A R Kilgore

¹George Williams Hooper Foundation for Medical Research, University of California Medical School, San Francisco.

The Journal of Experimental Medicine

|October 30, 2009

Summary

This summary is machine-generated.

Toxic proteoses accumulating in closed intestinal loops cause intoxication. This primary proteose, resistant to digestion, leads to symptoms mimicking intestinal obstruction in dogs.

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Area of Science:

Gastroenterology
Toxicology
Biochemistry

Background:

Intestinal obstruction leads to intoxication due to toxic material accumulation in closed loops.
Previous evidence suggests a specific 'loop poison' is responsible for this intoxication.

Purpose of the Study:

To identify the toxic substance responsible for intoxication in closed intestinal loops.
To characterize the properties of this toxic substance and its effects.

Main Methods:

Chemical analysis of the contents of closed intestinal loops.
Experimental intoxication of dogs with isolated toxic substances.
Autopsy and blood analysis of affected dogs.

Main Results:

A toxic substance, resistant to digestion and soluble in water, was identified.
This substance, isolated as primary proteoses, caused symptoms identical to intestinal loop intoxication in dogs.
Autopsy revealed splanchnic paralysis and organ engorgement, with blood changes including concentration and incoagulability.

Conclusions:

Experimental evidence points to a primary proteose as the essential toxic agent in closed intestinal loops and intestinal obstruction.
This toxic proteose is likely excreted by the kidneys, potentially explaining clinical improvement after transfusion.