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Updated: Jun 19, 2026
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Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
THE DISAPPEARANCE OF DEXTROSE FROM THE BLOOD AFTER INTRAVENOUS INJECTION
1Department of Physiology and Pharmacology of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Intravenous dextrose rapidly leaves a dog
Area of Science:
- Physiology
- Biochemistry
Background:
- Dextrose (glucose) is a primary energy source.
- Understanding dextrose metabolism is crucial for metabolic research.
Purpose of the Study:
- To investigate the disappearance rate and distribution of intravenously injected dextrose in dogs.
- To determine the physiological and non-physiological factors influencing dextrose removal from circulation.
Main Methods:
- Intravenous injection of large dextrose quantities into normal and nephrectomized dogs (living and dead).
- Ligation of major abdominal blood vessels (aorta, vena cava) to isolate circulation.
- Analysis of blood and muscle tissue carbohydrate levels.
Main Results:
- Dextrose disappeared from circulating blood within 90 minutes post-injection, with 60% excreted in urine.
- Dextrose removal occurred at similar rates in living, nephrectomized, and even dead animals.
- Dextrose transfer into tissues, particularly muscle, was confirmed, with evidence of polysaccharide formation.
Conclusions:
- Dextrose removal from blood is largely independent of kidney function and vital processes.
- The phenomenon involves rapid transfer to tissues, suggesting passive diffusion or non-vital mechanisms.
- Further research is needed to elucidate the precise mechanisms of dextrose tissue uptake and potential polysaccharide synthesis.
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