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STUDIES ON HETEROGENEOUS HEMOLYTIC SERA.

I L Kritchevsky1

  • 1Gabritchewsky Bacteriological Institute, University of Moscow, Moscow, Russia.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Sheep red blood cells carry antigens if the animal

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Area of Science:

  • Immunology
  • Serology

Background:

  • Nucleated red blood cells can contain heterogeneous sheep antigens.
  • Sera can contain both heterogeneous hemolysins and agglutinins.

Purpose of the Study:

  • To investigate the antigenic properties of red blood cells and sera.
  • To challenge existing theories on antigenicity.

Main Methods:

  • Immunization of rabbits with hen red blood cells.
  • Observation of hemolytic and anaphylactic reactions.

Main Results:

  • Hemolytic rabbit sera, generated using non-toxic hen red blood cells, induced anaphylactic shock in guinea pigs.
  • The presence of heterogeneous hemolysins and agglutinins in sera was confirmed.

Conclusions:

  • Heterogeneous hemolysins can be produced using non-toxic antigens.
  • This finding contradicts Friedberger's theory linking antigenicity solely to toxicity.