Related Experiment Video
Updated: Jun 19, 2026

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
Published on: January 10, 2025
CICATRIZATION OF WOUNDS : III. THE RELATION BETWEEN THE AGE OF THE PATIENT, THE AREA OF THE WOUND, AND THE INDEX OF
1Laboratories of The Rockefeller Institute for Medical Research, New York, and Hospital 21, Compiègne, France.
Abstract:
The first article of this series showed that it was possible to express mathematically the phenomenon of cicatrization. The principal point consisted in determining by means of an equation, a constant, or index, characterizing each wound. The calculation had to be made for each patient for each wound, and required two observations, 4 days apart. The index having proved to be a continuous function of the size of the wound and of the age of the patient, of the form See PDF for Equation where S is the area, i the index, a a decimal exponent, and K a constant, it was then possible to draw a chart by means of which this index i could be obtained without calculation. The advantage of the new way of determining the index is, above all, that this index is a general, average, normal index, and no longer an individual index. Hence, the differences between the observed rate of cicatrization of man and the normal rate may give some indication of the general state of the patient. Another advantage is that the determination of the index is no longer controlled by the temporary accidents which may happen between the two observations of S and S'.
Related Concept Videos
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Healing II: Complications
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the exudate's...
Healing I: Introduction
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

