Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pneumonia II: Pathophysiology

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...

Pneumonia III: Complications and Assessment

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:

Pneumonia IV: Management

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:

Mechanism of Breathing I: Inspiration

Mechanism of Breathing I: Inspiration

Introduction to Inspiration: The Respiratory System in Action
The respiratory system, an essential network for breathing, comprises the conducting and respiratory zones, each playing a crucial role in the overall process of respiration. Let us explore the detailed mechanism of inspiration, or inhalation, which is the first phase of the respiratory cycle.
Pathway of Air during Inspiration
During inspiration, air enters our body through the nose or mouth and moves through the conducting zone,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Basal Metabolism Determination in the Management of Thyroid Disease.

Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association·2011

Same author

An 18-hour concentration test of kidney function.

The American journal of the medical sciences·2010

Same author

Evaluation of the several methods for treating Graves' disease available today.

Annals of internal medicine·2010

Same author

Hyperophthalmopathic Graves' disease.

Annals of internal medicine·2010

Same author

Radiation pneumonitis; clinicopathological exercises.

The New England journal of medicine·2010

Same author

The clinical teaching of social medicine.

Bulletin of the Johns Hopkins Hospital·2010

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

THE RESPIRATORY MECHANISM IN PNEUMONIA.

L H Newburgh¹, J H Means, W T Porter

¹Departments of Comparative Physiology and Medicine of the Harvard Medical School, Boston.

The Journal of Experimental Medicine

|October 30, 2009

Summary

In pneumonia patients, the respiratory system's response to carbon dioxide is significantly reduced. This diminished response worsens with the severity of the pneumonia.

Area of Science:

Pulmonary Medicine
Respiratory Physiology

Background:

The respiratory system's chemosensitivity to carbon dioxide (CO2) is crucial for maintaining homeostasis.
Pneumonia, an inflammatory lung condition, can significantly impact respiratory function.

Purpose of the Study:

To investigate the impact of pneumonia on the respiratory mechanism's response to carbon dioxide.
To determine if disease severity correlates with the degree of diminished respiratory response.

Main Methods:

The study likely involved assessing respiratory responses (e.g., ventilation) to controlled levels of carbon dioxide in patients with pneumonia.
Comparison of responses between pneumonia patients and healthy controls, or across different pneumonia severity groups.

Main Results:

More Related Videos

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

Published on: September 28, 2016

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

Experimental Model to Evaluate Resolution of Pneumonia

Experimental Model to Evaluate Resolution of Pneumonia

Published on: February 17, 2023

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

A Non-invasive and Technically Non-intensive Method for Induction and Phenotyping of Experimental Bacterial Pneumonia in Mice

Published on: September 28, 2016

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia

Published on: June 28, 2018

The reaction of the respiratory mechanism to carbon dioxide is significantly diminished in individuals with pneumonia.
A clear correlation was observed: the graver the pneumonia, the less pronounced the respiratory response to carbon dioxide.

Conclusions:

Pneumonia impairs the normal chemosensitivity of the respiratory system to carbon dioxide.
The findings suggest that reduced CO2 responsiveness may be a contributing factor to respiratory complications in severe pneumonia.