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Related Experiment Video

Updated: Jun 19, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

THE ACTION OF DIGITALIS IN PNEUMONIA.

A E Cohn¹, R A Jamieson

¹Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Digitalis administration in pneumonia patients affects heart function, altering auriculoventricular conduction and T-wave patterns similarly to non-febrile cases. These cardiac changes are not due to pneumonia intoxication.

Area of Science:

Cardiology
Pharmacology

Background:

Pneumonia can affect cardiac function.
The impact of digitalis on the heart in febrile conditions like pneumonia requires investigation.

Purpose of the Study:

To determine if digitalis has a discernible effect on cardiac function in pneumonia patients.
To compare the cardiac effects of digitalis in pneumonia to its known effects in non-febrile states.

Main Methods:

Statistical analysis of 95 pneumonia cases treated with digitalis.
Electrocardiogram (ECG) monitoring for changes in auriculoventricular conduction time and T-wave morphology.
Comparison of cardiac response in febrile pneumonia patients to established responses in non-febrile individuals.

Main Results:

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Last Updated: Jun 19, 2026

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling

Published on: April 7, 2015

Digitalis administration altered auriculoventricular conduction time and T-wave morphology in pneumonia patients, consistent with effects in non-febrile hearts.
Pulse rate in cases of atrial fibrillation and flutter decreased with fever, mirroring non-febrile responses.
The T wave was more frequently and readily affected by digitalis than the conduction interval.

Conclusions:

Digitalis exerts a measurable cardiac action in pneumonia patients.
The observed cardiac effects are attributable to digitalis and not pneumonia intoxication or disease severity.
Heart muscle in pneumonia does not undergo changes that would preclude digitalis-induced conduction alterations.