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THE RELATION OF CIRCULATING ANTIBODIES TO SERUM DISEASE.
1Medical Clinic of the Presbyterian Hospital, Columbia University, New York.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Horse serum injections cause hypersensitivity, with antibodies like anaphylactin and precipitin appearing in patients with serum sickness. These antibodies help neutralize the antigen, leading to recovery from serum sickness.
Area of Science:
- Immunology
- Allergy Research
Background:
- Horse serum injections can lead to hypersensitivity in humans.
- Serum sickness is a known complication of horse serum administration.
Purpose of the Study:
- To investigate the immunological changes associated with horse serum injections.
- To determine the role of anaphylactin and precipitin in serum sickness.
Main Methods:
- Monitoring human subjects receiving horse serum injections.
- Analyzing blood serum for the presence of anaphylactin and precipitin.
- Correlating antibody presence with clinical symptoms of serum sickness.
Main Results:
- Hypersensitivity to horse serum develops after injections, independent of serum sickness.
- Anaphylactin and precipitin are detected in the serum of patients with serum sickness.
- Antibody levels rise before recovery, coinciding with antigen clearance.
- Antibody presence is linked to antigen neutralization and recovery.
Conclusions:
- The development of anaphylactin and precipitin in response to horse serum is a key immunological event.
- These antibodies play a crucial role in neutralizing the horse serum antigen.
- The presence of antibodies is indicative of the body's defense mechanism leading to recovery from serum sickness.
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