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EXPERIMENTS ON THE ROLE OF LYMPHOID TISSUE IN THE RESISTANCE TO EXPERIMENTAL TUBERCULOSIS IN MICE : III. EFFECT OF

J B Murphy1, E Sturm

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Mice with high lymphocyte counts and increased activity of the lymphoid tissue induced by one exposure to intense dry heat exhibit a marked increase in the resistance to large doses of bovine tubercle bacilli as compared with that shown by control animals given a similar inoculation. This resistance, judged by the time of survival after inoculation, is increased from two- to threefold. The average length of life after inoculation for three groups of heated mice was 88, 69, and 67 days respectively, while the control groups averaged 16, 29, and 28 days respectively.

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