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STUDIES ON MEASLES : I. SUSCEPTIBILITY OF MONKEYS TO THE VIRUS OF MEASLES
The Journal of Experimental Medicine
|October 30, 2009
Summary
Researchers induced measles-like symptoms in monkeys by inoculating them with filtered and unfiltered nasopharyngeal washings from measles patients. This study demonstrates successful transmission and supports measles virus as the causative agent.
Area of Science:
- Virology
- Infectious Diseases
- Primatology
Background:
- Measles is a highly contagious viral illness.
- Understanding the early stages and transmission of measles is crucial for disease control.
Purpose of the Study:
- To investigate the possibility of inducing measles-like symptoms in non-human primates.
- To identify the causative agent of measles through experimental transmission.
Main Methods:
- Intratracheal inoculation of monkeys with nasopharyngeal washings from measles patients.
- Filtration of washings to exclude bacterial contamination.
- Serial passage of the induced reaction through multiple monkeys.
- Intravenous inoculation with citrated whole blood.
Main Results:
- Consistent induction of measles-like symptoms in monkeys following inoculation.
- Successful serial transmission of the reaction via intratracheal and intravenous routes.
- Elimination of bacterial contamination as the cause of symptoms.
- Histopathological analysis revealed lesions similar to those in human measles.
Conclusions:
- The study provides strong evidence that an infectious agent in nasopharyngeal washings causes measles-like symptoms in monkeys.
- The successful transmission experiments support the hypothesis that measles is caused by a filterable virus.
- The induced reaction closely mimics human measles, offering a valuable model for further research.
