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Myelin Oligodendrocyte Glycoprotein (MOG35-55) Induced Experimental Autoimmune Encephalomyelitis (EAE) in C57BL/6 Mice
Published on: April 15, 2014
EXPERIMENTAL MUMPS MENINGITIS
1Laboratories of The Rockefeller Institute for Medical Research.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Researchers induced aseptic meningitis in cats using sterile saliva filtrate from parotitis cases. This meningitis, characterized by a favorable prognosis, was transmissible via cerebrospinal fluid, which remained bacteria-free.
Area of Science:
- Veterinary Neurology
- Infectious Diseases
- Pathology
Background:
- Parotitis, or mumps, can cause neurological complications.
- Aseptic meningitis is inflammation of the meninges not caused by bacterial infection.
- Understanding the transmission and etiology of meningitis is crucial for animal health.
Purpose of the Study:
- To investigate the potential for inducing aseptic meningitis in cats.
- To determine if the induced meningitis is transmissible between feline subjects.
- To identify the causative agent of this experimentally induced meningitis.
Main Methods:
- Intrathecal injection of sterile saliva filtrate from early parotitis cases in cats.
- Subsequent injection of cerebrospinal fluid from affected cats into naive cats.
- Bacteriological culture of cerebrospinal fluid to assess for microbial presence.
Main Results:
- Aseptic meningitis with a 3-5 day duration and favorable prognosis was successfully induced in cats.
- The induced meningitis was transmissible to other cats via cerebrospinal fluid.
- Cerebrospinal fluid samples remained consistently bacteria-free throughout the study.
Conclusions:
- Sterile saliva filtrate from parotitis cases can induce transmissible aseptic meningitis in cats.
- The causative agent is non-bacterial and likely viral or other acellular infectious agent.
- This model provides insights into the pathogenesis of certain types of meningitis.
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