Related Experiment Video
Updated: Jun 19, 2026

05:54
Quantification of Diabetes-induced Adherent Leukocytes in Retinal Vasculature
Published on: January 24, 2025
ON ALIMENTARY LEUCOCYTOSIS IN ITS RELATION TO THE "CRISE HEMOCLASIQUE" OF WIDAL
W Storm van Leeuwen1, Z Bien, H Varekamp
1Pharmacotherapeutical Institute of the University of Leiden, Leiden, Holland.
The Journal of Experimental Medicine
|October 30, 2009
Summary
Post-meal white blood cell counts in normal and asthmatic individuals show a rapid drop followed by a rise, suggesting blood distribution changes rather than a "crise hémoclasique". This pattern cannot identify food hypersensitivities.
Area of Science:
- Hematology
- Immunology
- Gastroenterology
Background:
- Postprandial changes in white blood cell counts are complex.
- The
- crise hémoclasique
- is a proposed reaction to food or drugs.
Purpose of the Study:
- To investigate white blood cell count fluctuations after meals in normal and asthmatic individuals.
- To determine if these fluctuations indicate a
- crise hémoclasique
- .
Main Methods:
- Counting white blood cells at short intervals after consuming various meals (meat, eggs, milk, rice, butter).
- Comparing leucocytic curves in normal individuals versus asthmatics.
- Observing changes in red blood cells, leucocytic formula, and blood pressure.
Main Results:
- A rapid fall in white blood cells typically occurs within 1-2 minutes post-meal, followed by a rise.
- A secondary fall and subsequent rise (physiological leucocytosis) may occur.
- Observed leucopenia is likely due to altered blood distribution, not a
- crise hémoclasique
- .
Conclusions:
- The postprandial leucocyte curve's variability makes it unsuitable for identifying causative agents of hypersensitivity.
- Further research is needed to determine if the full syndrome of
- crise hémoclasique
- symptoms can identify hypersensitivities.
Related Concept Videos
Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Structure and Function of Leukocytes
An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
White blood cells protect the body...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Classification of Leukocytes
Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Leishmaniasis
Leishmaniasis is a protozoal disease caused by species of the genus Leishmania and transmitted through the bite of infected female sandflies. The parasite exists in two principal morphological forms during its life cycle. A sandfly acquires intracellular amastigotes from an infected reservoir host, such as a dog. Within the sandfly, these forms differentiate into motile, flagellated promastigotes. During a subsequent blood meal, promastigotes are injected into the human host, where they...

