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Related Concept Videos

X-ray Imaging01:24

X-ray Imaging

German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with X-rays, and by 1900, X-ray was widely...

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Related Experiment Video

Updated: Jun 19, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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EXPERIMENTAL RICKETS IN RATS : VIII. THE EFFECT OF ROENTGEN RAYS.

A F Hess1, L J Unger, J M Steiner

  • 1Department of Pathology of the College of Physicians and Surgeons, Columbia University, New York.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Soft Roentgen rays did not prevent rickets in rats fed a low phosphorus diet. Massive doses of these rays also failed to induce rickets in rats with adequate dietary phosphate.

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Last Updated: Jun 19, 2026

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

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Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
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Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

Area of Science:

  • Biochemistry
  • Radiology
  • Animal models

Background:

  • Rickets is a condition characterized by soft, weak bones, often caused by vitamin D or phosphate deficiency.
  • The effects of radiation on bone metabolism and development are not fully understood.
  • Investigating the potential therapeutic or detrimental effects of Roentgen rays on bone health is crucial.

Purpose of the Study:

  • To determine if soft Roentgen rays can prevent rickets in rats with low phosphorus intake.
  • To assess whether massive doses of Roentgen rays can induce rickets in rats with adequate phosphate levels.

Main Methods:

  • Rats were fed a low phosphorus diet and exposed to soft Roentgen rays.
  • Rats were fed an adequate phosphate diet and exposed to massive doses of Roentgen rays.
  • Bone health and marrow were assessed.

Main Results:

  • Soft Roentgen ray exposure did not prevent rickets in rats on a low phosphorus diet.
  • Massive Roentgen ray doses did not induce rickets in rats with sufficient dietary phosphate.
  • High-intensity Roentgen rays caused significant destruction of blood-forming cells in the bone marrow.

Conclusions:

  • Soft Roentgen rays are ineffective in preventing diet-induced rickets.
  • Roentgen ray exposure, even at high doses, does not appear to cause rickets when phosphate levels are adequate.
  • High-intensity Roentgen rays have detrimental effects on bone marrow, independent of rickets development.