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Related Concept Videos

Classification of Leukocytes01:30

Classification of Leukocytes

Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
Neutrophils are the most abundant type of granular leukocytes, comprising 50-70% of all leukocytes. They feature small, evenly distributed granules and a...
Exocrine Glands: Types of Secretions01:13

Exocrine Glands: Types of Secretions

Exocrine glands produce and release a variety of glandular products. Exocrine glands can be classified into serous, mucous, or mixed types based on their secretory products.
Serous glands produce watery secretions rich in digestive enzymes and proteins. The constituent cells of the serous gland have centrally located nuclei and eosinophilic secretory granules in the cytoplasm. The parotid gland is an example of a serous gland. It secretes saliva, which contains enzymes, such as lipases and...
Structure and Function of Leukocytes01:21

Structure and Function of Leukocytes

An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
White blood cells protect the body...
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine glands...
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...

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Updated: Jun 19, 2026

Purification of Pathogen Vacuoles from Legionella-infected Phagocytes
09:25

Purification of Pathogen Vacuoles from Legionella-infected Phagocytes

Published on: June 19, 2012

LEUCOCYTIC SECRETIONS.

A Carrel1, A H Ebeling

  • 1Laboratories of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Leucocytes secrete substances that promote homologous cell growth and can lyse foreign cells. These secretions, analogous to embryonic tissue factors, may play a role in tissue repair and immune defense.

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Harvest and Primary Culture of Leptomeningeal Lymphatic Endothelial Cells
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Harvest and Primary Culture of Leptomeningeal Lymphatic Endothelial Cells

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Purification of Pathogen Vacuoles from Legionella-infected Phagocytes
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Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages
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Harvest and Primary Culture of Leptomeningeal Lymphatic Endothelial Cells
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Harvest and Primary Culture of Leptomeningeal Lymphatic Endothelial Cells

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Area of Science:

  • Cell Biology
  • Immunology
  • Tissue Engineering

Background:

  • Studying leucocytic secretions was limited by methods involving serum and potential cell destruction.
  • Leucocytes are known to interact with tissue cells, but the nature of these secretions was unclear.
  • The origin of protective substances like alexin and antibodies from leucocytes was under investigation.

Purpose of the Study:

  • To investigate the physiological effects of leucocytic secretions on homologous and foreign cells.
  • To determine if leucocytes secrete growth-activating substances spontaneously or under stimulation.
  • To ascertain if leucocytic secretions enhance natural hemolytic effects and respond to foreign proteins.

Main Methods:

  • Culturing leucocytes in a controlled medium and analyzing the properties of the extracted serum.
  • Comparing the effects of serum from leucocyte cultures versus control media on cell proliferation and hemolysis.
  • Assessing changes in serum properties after incubation at different temperatures and in the presence of foreign protein (casein).

Main Results:

  • Leucocyte cultures consistently produced serum that promoted homologous fibroblast growth.
  • Leucocytic secretions occasionally exhibited hemolytic activity against foreign erythrocytes.
  • Foreign protein (casein) stimulated leucocytic secretions, enhancing homologous cell activity but not consistently increasing hemolytic effects.

Conclusions:

  • Leucocytes secrete growth-promoting substances analogous to those in embryonic tissues, potentially aiding in wound repair and tissue regeneration.
  • Leucocytes can also release substances toxic to foreign cells, contributing to immune defense.
  • The study provides qualitative insights into leucocytic secretions, highlighting their dual role in promoting tissue repair and combating foreign agents.