Related Experiment Video
Updated: Jun 19, 2026

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
BLOOD DESTRUCTION DURING EXERCISE : III. EXERCISE AS A BONE MARROW STIMULUS
1Laboratories of The Rockefeller Institute for Medical Research.
Abstract:
A definite increase in the percentage of reticulocytes occurs after exercise in animals previously kept to a sedentary life. Concomitant changes in the hemoglobin percentage, plasma-cell ratio, and red count offer evidence in addition to that already reported by the author of the occurrence of an increase in blood destruction under such circumstances. Replacement by transfusion of blood destroyed during exercise prevents the reticulated cell reaction. Animals rendered plethoric and then exercised show no increase in reticulated cells while the plethora persists. The fact is emphasized that exercise must be an important factor in the maintenance of an efficient hematopoietic tissue.
Related Concept Videos
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Factors Affecting Erythropoiesis
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
Erythropoiesis
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Blood and Nerve Supply to the Bones
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Overview of Hematopoiesis
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
