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Related Experiment Video

Updated: Jun 19, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

THE SOLUBLE SPECIFIC SUBSTANCE OF PNEUMOCOCCUS.

M Heidelberger¹, O T Avery

¹Hospital of The Rockefeller Institute for Medical Research.

The Journal of Experimental Medicine

|October 30, 2009

Summary

Researchers developed a method to purify pneumococcus soluble specific substance, finding it is likely a glucose-based polysaccharide. Further research is needed to confirm if it is the substance itself or associated with it.

Area of Science:

Microbiology
Biochemistry

Background:

Pneumococcus is a bacterium that causes various infections.
Understanding its specific substances is crucial for developing treatments.

Purpose of the Study:

To develop a method for concentrating and purifying the soluble specific substance of pneumococcus.
To characterize the chemical nature of this purified substance.

Main Methods:

A novel method was employed for the concentration and purification of the soluble specific substance.
Chemical analysis was performed on the purified material.

Main Results:

The purified substance primarily consists of a carbohydrate.
This carbohydrate appears to be a polysaccharide composed of glucose molecules.

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Last Updated: Jun 19, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

Using the Overlay Assay to Qualitatively Measure Bacterial Production of and Sensitivity to Pneumococcal Bacteriocins

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Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

Investigating the Effects of Probiotics on Pneumococcal Colonization Using an In Vitro Adherence Assay

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Conclusions:

The soluble specific substance of pneumococcus is likely a polysaccharide.
Further investigation is required to definitively establish whether the substance is the polysaccharide itself or associated with it.