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Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
AN INFECTIOUS OPHTHALMIA OF CATTLE.
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N. J.
The Journal of Experimental Medicine
|October 30, 2009
Summary
A novel diplobacillus causes acute cattle ophthalmia, leading to severe eye inflammation, ulcers, and opacity. This finding aids in diagnosing and understanding this significant bovine eye infection.
Area of Science:
- Veterinary Ophthalmology
- Bovine Infectious Diseases
- Microbiology
Background:
- Acute ophthalmia in cattle presents a significant challenge in livestock health.
- Previous understanding of the causative agents and pathogenesis of this condition is limited.
Purpose of the Study:
- To identify the causative agent of acute ophthalmia in cattle.
- To characterize the clinical signs and pathological changes associated with the infection.
- To experimentally reproduce the disease in healthy cattle.
Main Methods:
- Clinical observation of 24 affected cattle.
- Isolation and characterization of the etiological agent from ocular exudates.
- Microscopic examination, assessment of hemolytic and proteolytic properties.
- Experimental inoculation of pure bacterial cultures into healthy cattle.
Main Results:
- A characteristic diplobacillus was consistently isolated from all cases.
- Clinical signs included photophobia, conjunctivitis, eyelid edema, and mucopurulent discharge.
- Corneal ulcers and opacities developed in some cases.
- Experimental inoculation successfully reproduced the disease, confirming the bacterium's pathogenicity for cattle.
- The organism was not pathogenic for laboratory animals.
Conclusions:
- A specific diplobacillus is identified as the causative agent of acute cattle ophthalmia.
- The identified organism's morphology and biochemical properties facilitate its diagnosis.
- This research provides crucial insights into the etiology and pathogenesis of bovine ophthalmia.
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