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Updated: Jun 19, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
Published on: June 13, 2019
INDICATIONS OF TISSUE SPECIFICITY IN A TRANSPLANTABLE SARCOMA
1Department of Biology of St. Stephen's College, Annandale-on-the-Hudson, and the Carnegie Institution of Washington, Cold Spring Harbor.
Abstract:
1. A sarcoma of the mouse which has proved to be transplantable to a great variety of strains of mice does not furnish an exception to the theory that transplantability is controlled by genetic factors, since this tumor possesses some characteristics that are more than probably genetic. 2. The phenomenon of the assumption of tissue specificity on the part of the host may possibly be of genetic origin. 3. The evidence suggests that the gonads have some influence on the assumption of tissue specificity on the part of the host. 4. The growth rate of the transplanted tumor may possibly be correlated with the genetic constitution of the host.

