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Related Concept Videos

Intestinal Obstruction II: Pathophysiology01:07

Intestinal Obstruction II: Pathophysiology

Intestinal obstruction triggers a series of physiological responses, starting with gas and fluid accumulation in the bowel segment proximal to the obstruction, leading to distension. This distended intestine compresses the diaphragm, hindering lung expansion and potentially leading to reduced respiratory effort, atelectasis, and pneumonia.To overcome the blockage, the gut intensifies contractions, causing colicky abdominal pain, nausea, and vomiting, which reduces fluid and food intake and...
Intestinal Obstruction I: Introduction01:29

Intestinal Obstruction I: Introduction

Intestinal obstruction is a partial or complete blockage of the small or large intestine that disrupts the normal flow of intestinal contents through the lumen. This interruption impairs digestion, absorption, and fluid balance, and may lead to serious complications if not treated promptly.Mechanical ObstructionMechanical obstruction occurs when a physical blockage prevents intestinal contents from passing, arising from within the lumen or the bowel wall, or from external compression.Adhesions,...
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Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

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Postoperative Ileus Murine Model
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EXPERIMENTAL HIGH INTESTINAL OBSTRUCTION IN THE MONKEY.

R L Haden1, T G Orr

  • 1University of Kansas School of Medicine, Kansas City, Kansas.

The Journal of Experimental Medicine
|October 30, 2009
PubMed
Summary
This summary is machine-generated.

Experimental high intestinal obstruction in monkeys caused a rise in non-protein nitrogen, similar to humans and dogs. Blood chloride levels dropped, and CO(2)-combining power increased, even without vomiting.

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Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Area of Science:

  • Veterinary Medicine
  • Gastroenterology
  • Primate Research

Background:

  • Intestinal obstruction is a critical condition with significant physiological consequences.
  • Previous studies in humans and dogs have documented characteristic blood changes.

Purpose of the Study:

  • To investigate the hematological changes associated with experimental high intestinal obstruction in non-human primates.
  • To compare primate responses to known patterns in other species.

Main Methods:

  • Five monkeys underwent experimental high intestinal obstruction.
  • Blood samples were analyzed for non-protein nitrogen, chlorides, CO(2)-combining power, uric acid, and creatinine.

Main Results:

  • All monkeys exhibited elevated non-protein nitrogen levels.
  • A significant decrease in blood chlorides was observed in two monkeys, with a lesser fall in others.
  • Increased CO(2)-combining power correlated with chloride level changes.
  • Uric acid and creatinine showed no consistent alterations.
  • Vomiting was not observed in any of the subjects.

Conclusions:

  • High intestinal obstruction in monkeys elicits distinct blood chemistry alterations, including elevated non-protein nitrogen and decreased chlorides.
  • The observed changes in blood chemistry, particularly the fall in chlorides and rise in CO(2)-combining power, occur independently of vomiting.
  • These findings in primates contribute to understanding the pathophysiology of intestinal obstruction across species.