Related Experiment Video
Updated: Jun 19, 2026

Procedures for In Vitro Cultivation of Treponema pallidum, the Syphilis Spirochete
Published on: January 24, 2025
STUDIES IN EXPERIMENTAL SYPHILIS : II. THE INFLUENCE OF A NON-SPECIFIC INFLAMMATORY REACTION UPON THE DEVELOPMENT OF
1Department of Medicine of the Johns Hopkins Medical School, Baltimore.
Abstract:
Rabbits can be successfully infected with syphilis by the inoculation of surface wounds with virulent strains of Treponema pallidum. Old granulating wounds in these animals constitute a particularly favorable terrain for syphilis inoculation, the chancre developing relatively soon and attaining a greater size than the lesion occurring on the basis of a fresh wound. Coal tar dermatitis renders the skin susceptible to infection with Treponema pallidum. The possible reasons for these phenomena are discussed and an hypothesis to account for them is advanced.
Related Concept Videos
Chronic Inflammation: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Acute Inflammation III: Local and Systemic Effects
Acute Inflammation II: Cellular Phase
