Related Experiment Video
Updated: Jun 19, 2026

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
Published on: February 19, 2019
THE LIVER AS A SOURCE OF BACTERIAL AGGLUTININ
1Department of Animal Pathology of The Rockefeller Institute for Medical Research, Princeton, N.J.
Abstract:
Serum and tissues containing agglutinin for the hog cholera bacillus may be dried in vacuo over sulfuric acid without appreciably injuring the antibody. The desiccated material when extracted with appropriate amounts of distilled water offers a basis for accurate comparison of antibody content. The greatest concentration of agglutinin occurred in the liver, provided the animals injected with small amounts of antigen were killed within a short period. The serum of those more highly immunized contained the greatest concentration of antibody. A single injection of antigen into a radicle of the mesenteric vein resulted in a considerable concentration of agglutinin in the liver. Other experiments indicated that the liver does not act as a reservoir for the antibody. It has also been shown that this concentration of agglutinin cannot be ascribed to the blood left within the liver, since the blood serum was relatively poor in antibody. The experiments indicate that the agglutinin was produced within the liver.
Related Concept Videos
Liver Histology
Hepatocytes perform a variety of essential functions. They secrete...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can also...
Hepatitis
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Gross Anatomy of the Liver
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is covered...
